Concepedia

Timothy K. MacLachlan

TK

27

Publications

1.8K

Citations

22

H-Index

1995

Active since

Affiliations

University of Pennsylvania(Current)

Howard Hughes Medical Institute

Novartis (United States)

Thomas Jefferson University

Jefferson Institute

Timothy K. MacLachlan is an author at University of Pennsylvania specializing in medicine, cell biology, and tumor biology.

Top concepts

Publications per year

1995–2023

27

Publications

27

BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression

Timothy K. MacLachlan, Kumaravel Somasundaram, Magda Sgagias et al. · Journal of Biological Chemistry · 2000 · 213 citations · Full text

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Preclinical Safety Evaluation of AAV2-sFLT01— A Gene Therapy for Age-related Macular Degeneration

Timothy K. MacLachlan, Michael Lukason, Margaret E. Collins et al. · Molecular Therapy · 2010 · 163 citations · Full text

Apoptotic threshold is lowered by p53 transactivation of caspase-6

Timothy K. MacLachlan, Wafik S. El‐Deiry · Proceedings of the National Academy of Sciences · 2002 · 162 citations · Full text

, , +12

BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets

Timothy K. MacLachlan, Rishu Takimoto, Wafik S. El‐Deiry · Molecular and Cellular Biology · 2002 · 160 citations · Full text

CRISPR-Cas9 Editing of the <i>HBG1</i> and <i>HBG2</i> Promoters to Treat Sickle Cell Disease

Akshay Sharma, Jaap Jan Boelens, Maria Cancio et al. · New England Journal of Medicine · 2023 · 138 citations · Full text

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