Timothy K. MacLachlan

Author

Also Known As

Jon Giblin, T K MacLachlan, T. MacLachlan, T. Maclachlan, T.K. MacLachlan, Timothy K MacLachlan, Timothy K. MacLachlan, Timothy K. Maclachlan, Timothy MacLachlan, Timothy Maclachlan

Publications

2.1K

Citations

H-Index

Concepts

All Affiliations

University of Pennsylvania Howard Hughes Medical Institute Novartis (United States)Thomas Jefferson University Jefferson Institute

About

Timothy K. MacLachlan is an author at University of Pennsylvania specializing in medicine, cell biology, and tumor biology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	13	15	941
2	Natural Sciences	5	5	175
3	Engineering	2	2	38
4	Health Sciences	1	1	29
5	Public Health	1	1	213

Timothy K. MacLachlan

Publications

1.8K

Citations

H-Index

Page 1

	Year	Citations
BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression Timothy K. MacLachlan, Kumaravel Somasundaram, Magda Sgagias, Journal of Biological Chemistry Dna DamageGeneticsGenomic MechanismCell CycleCancer Biology	2000	213
Preclinical Safety Evaluation of AAV2-sFLT01— A Gene Therapy for Age-related Macular Degeneration Timothy K. MacLachlan, Michael Lukason, Margaret E. Collins, Molecular Therapy	2010	163
Apoptotic threshold is lowered by p53 transactivation of caspase-6 Timothy K. MacLachlan, Wafik S. El‐Deiry Proceedings of the National Academy of Sciences Executioner CaspaseChemoprevention StrategyMedicineApoptosisImmunology	2002	162
BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets Timothy K. MacLachlan, Rishu Takimoto, Wafik S. El‐Deiry Molecular and Cellular Biology	2002	160
CRISPR-Cas9 Editing of the <i>HBG1</i> and <i>HBG2</i> Promoters to Treat Sickle Cell Disease Akshay Sharma, Jaap Jan Boelens, Maria Cancio, New England Journal of Medicine	2023	138
Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. Florencia Bullrich, Timothy K. MacLachlan, Nianli Sang, PubMed Cdc2 FamilyPathologyCell CycleCancer BiologyTumor Biology	1995	110
Inhibition of Choroidal Neovascularization in a Nonhuman Primate Model by Intravitreal Administration of an AAV2 Vector Expressing a Novel Anti-VEGF Molecule Michael Lukason, Elizabeth DuFresne, Hillard Rubin, Molecular Therapy Ocular DiseaseRetinal NeovascularizationImmunologyChoroidal NeovascularizationCnv Lesions	2010	82
BRCA1 Transcriptionally Regulates Damaged DNA Binding Protein (DDB2) In the DNA Repair Response Following UV-Irradiation Rishu Takimoto, Timothy K. MacLachlan, David T. Dicker, Cancer Biology & Therapy	2002	82
A Unique Domain of pRb2/p130 Acts as an Inhibitor of Cdk2 Kinase Activity Antonio De Luca, Timothy K. MacLachlan, Luigi Bagella, Journal of Biological Chemistry	1997	81
BRCA1 Augments Transcription by the NF-κB Transcription Factor by Binding to the Rel Domain of the p65/RelA Subunit Miriam Benezra, Nathalie Chevallier, D. Morrison, Journal of Biological Chemistry Brca1 ProteinMolecular BiologyCell DeathCancer BiologyTumor Biology	2003	77

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