Hugues Dolgos

In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

Richard A. Thompson, Emre M. Isin, Yan Li et al. · Chemical Research in Toxicology · 2012 · 214 citations

Pharmacy, Pharmacology, Toxicology +17

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

Richard A. Thompson, Emre M. Isin, Yan Li et al. · Chemico-Biological Interactions · 2010 · 102 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Evaluating the Role of Solubility in Oral Absorption of Poorly Water‐Soluble Drugs Using Physiologically‐Based Pharmacokinetic Modeling

Christina Fink, Dajun Sun, Knut Wagner et al. · Clinical Pharmacology & Therapeutics · 2019 · 96 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Requirements to Establishing Confidence in Physiologically Based Pharmacokinetic (PBPK) Models and Overcoming Some of the Challenges to Meeting Them

Sheila Annie Peters, Hugues Dolgos · Clinical Pharmacokinetics · 2019 · 78 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +11

Evaluation of the Use of Static and Dynamic Models to Predict Drug-Drug Interaction and Its Associated Variability: Impact on Drug Discovery and Early Development

Sheila Annie Peters, Patricia Schroeder, Nagdeep Giri et al. · Drug Metabolism and Disposition · 2012 · 45 citations

Pharmacy, Pharmacokinetics, Pharmacology +17