Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

Laura D. Gamble, Stefania Purgato, Jayne Murray, +30

Science Translational Medicine

The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

Miriam A. Lynn, Georgina L. Eden, Feargal J. Ryan, +20

Cell Reports

Microbiota StructureDysbiosisPam IiMedicinePost-antibiotic Microbiota +13

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma

Livingstone Fultang, Laura D. Gamble, Luciana Gneo, +20

Cancer Research

Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy

Alvin Kamili, Andrew J. Gifford, Nancy Li, +13

British Journal of Cancer

Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition

Aaminah Khan, Emanuele Valli, Hayley Lam, +13

Oncogene

Neuro-oncologyDrug TargetingChemoprevention StrategyGliomaMedicine +9

A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines

Feargal J. Ryan, Todd S. Norton, Conor McCafferty, +24

Cell Reports Medicine

<i>In vitro</i> and <i>in vivo</i> drug screens of tumor cells identify novel therapies for high‐risk child cancer

Loretta M. S. Lau, Chelsea Mayoh, Jinhan Xie, +47

EMBO Molecular Medicine

Tumor BiologyOncologyHigh‐risk Child CancerMedicineCancer Cell Biology +9

The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota

Stephen J. Blake, Jane James, Feargal J. Ryan, +15

Cell Reports Medicine

DysbiosisImmunologyImmunoeditingPathologyGut Microbiota +18

Emu Oil Combined with Lyprinol™ Reduces Small Intestinal Damage in a Rat Model of Chemotherapy-Induced Mucositis

Suzanne Mashtoub, Lorrinne S Lampton, Georgina L. Eden, +4

Nutrition and Cancer

InflammationAnti-inflammatoryChemotherapy-induced MucositisAllergyMucosal Immunology +11

Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

Lin Xiao, Klaartje Somers, Jayne Murray, +35

Clinical Cancer Research