NAD+ metabolism governs the proinflammatory senescence-associated secretome

Timothy Nacarelli, Lena Lau, Takeshi Fukumoto, +14

Nature Cell Biology

Cellular SenescenceNad+ MetabolismMedicineCell BiologyOxidative Stress

Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils

Michela Perego, Vladimir A. Tyurin, Yulia Y. Tyurina, +14

Science Translational Medicine

N6-Methylation of Adenosine of <i>FZD10</i> mRNA Contributes to PARP Inhibitor Resistance

Takeshi Fukumoto, Hengrui Zhu, Timothy Nacarelli, +9

Cancer Research

m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype

Pingyu Liu, Fuming Li, Jianhuang Lin, +6

Nature Cell Biology

Mettl14 RedistributionGeneticsGenomic MechanismCellular SenescenceMolecular Genetics +5

NAMPT Inhibition Suppresses Cancer Stem-like Cells Associated with Therapy-Induced Senescence in Ovarian Cancer

Timothy Nacarelli, Takeshi Fukumoto, Joseph A. Zundell, +5

Cancer Research

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

Chad A. Lerner, Alessandro Bitto, Daniel Pulliam, +5

Aging Cell

MitophagyRapamycin ActivityCell DeathMitochondrial BiologyNuclear Genes +20

Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma

Shuai Wu, Takeshi Fukumoto, Jianhuang Lin, +18

Nature Cancer

Oncogenic AgentMedicineGls1 InhibitionTumor SuppressorGlutamine Dependence +5

Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer

Takeshi Fukumoto, Pyoung Hwa Park, Shuai Wu, +12

Cell Reports

Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization

Osamu Iwasaki, Hideki Tanizawa, Kyoung-Dong Kim, +7

Nature Communications

Lifespan ExtensionReplicative SenescenceSystems BiologySignal TransductionCompartmental Reorganization +13

Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence

Bo Zhao, Pingyu Liu, Takeshi Fukumoto, +9

Nature Communications