Sophie M. Bertrand

Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site

Jingsong Yang, Nino Campobasso, Mangatt P. Biju et al. · Chemistry & Biology · 2011 · 113 citations

Signal Transduction, Cell Signaling, Myristoyl Binding Site +11

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits

Sophie M. Bertrand, Nicolas Ancellin, Benjamin Beaufils et al. · Journal of Medicinal Chemistry · 2015 · 42 citations · Full text

Ligand Efficiency, Molecular Biology, Pharmacotherapy +17

Modular Access to Eight‐Membered N‐Heterocycles by Directed Carbonylative C−C Bond Activation of Aminocyclopropanes

Olivia Boyd, Gang‐Wei Wang, Olga O. Sokolova et al. · Angewandte Chemie International Edition · 2019 · 34 citations · Full text

Novel Organocatalysts, Eight‐membered N‐heterocycles, Engineering +15

Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles

Gang‐Wei Wang, Olivia Boyd, Tom A. Young et al. · Journal of the American Chemical Society · 2020 · 33 citations · Full text

Complex Polyheterocycles, Chemical Engineering, Novel Organocatalysts +13

Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening

Alan D. Borthwick, Nicolas Ancellin, Sophie M. Bertrand et al. · Journal of Medicinal Chemistry · 2016 · 30 citations · Full text

Bioorganic Chemistry, Structural Bioinformatics, Biomolecular Structure Prediction +20