Howard T. Jacobs

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Aleksandra Trifunović, Anna Wredenberg, Maria Falkenberg et al. · Nature · 2004 · 2.7K citations

Aging, Mitochondrial Function, Longevity +3

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Evanna L. Mills, Beth Kelly, Angela Logan et al. · Cell · 2016 · 2.1K citations · Full text

Inflammation, Mitochondrial Function, Biochemistry +9

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria

Johannes N. Spelbrink, Fang-Yuan Li, Valeria Tiranti et al. · Nature Genetics · 2001 · 879 citations

Mitochondrial Biogenesis, Mitochondrial Function, Mitochondrial Dynamic +8

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

Aleksandra Trifunović, Anna Hansson, Anna Wredenberg et al. · Proceedings of the National Academy of Sciences · 2005 · 555 citations · Full text

Mitochondrial Theory, Dna Damage, Aging +18

Mitochondria are physiologically maintained at close to 50 °C

Dominique Chrétien, Paule Bénit, Hyung‐Ho Ha et al. · PLoS Biology · 2018 · 419 citations · Full text

Molecular Biology, Mitochondrial Biology, Redox Biology +22