Paul J. Meakin

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Kenneth R. Watterson, Dawn Bestow, Jennifer Gallagher et al. · Neurosignals · 2012 · 3.4K citations · Full text

Life Sciences, Endocrinology, Physiology +17

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.8K citations

Life Sciences, Biochemistry, Cell Biology +12

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

Sudhir Chowdhry, Maiiada Nazmy, Paul J. Meakin et al. · Free Radical Biology and Medicine · 2009 · 261 citations

Medicine, Molecular Medicine, Pathology +12

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

Paul J. Meakin, Sudhir Chowdhry, Ritu Sharma et al. · Molecular and Cellular Biology · 2014 · 225 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

Karen Bell, Bashayer Al‐Mubarak, Marc-André Martel et al. · Nature Communications · 2015 · 195 citations · Full text

Life Sciences, Neurobiology, Neuroscience +15