Christopher S. Brower

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments

Konstantin Piatkov, Christopher S. Brower, Alexander Varshavsky · Proceedings of the National Academy of Sciences · 2012 · 141 citations · Full text

Neurodegeneration-Associated Protein Fragments as Short-Lived Substrates of the N-End Rule Pathway

Christopher S. Brower, Konstantin Piatkov, Alexander Varshavsky · Molecular Cell · 2013 · 117 citations · Full text

Neurodegenerative Diseases, Short-lived Substrates, Medicine +10

Ablation of Arginylation in the Mouse N-End Rule Pathway: Loss of Fat, Higher Metabolic Rate, Damaged Spermatogenesis, and Neurological Perturbations

Christopher S. Brower, Alexander Varshavsky · PLoS ONE · 2009 · 82 citations · Full text

Spermatogenesis, Metabolic Rate, Cell Death +23

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase

Christopher S. Brower, Shigeo Sato, Chieri Tomomori‐Sato et al. · Proceedings of the National Academy of Sciences · 2002 · 82 citations · Full text

Glutamine-Specific N-Terminal Amidase, a Component of the N-End Rule Pathway

Haiqing Wang, Konstantin Piatkov, Christopher S. Brower et al. · Molecular Cell · 2009 · 78 citations · Full text

Glutamine-specific N-terminal Amidase, Cellular Enzymology, Biochemistry +6