Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Christoph S. N. Klose, Melanie Flach, Luisa Möhle, +14

Cell

Type 1Common ProgenitorLymphocyte DevelopmentAdaptive Immune SystemImmunology +4

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

Christoph S. N. Klose, Elina A. Kiss, Vera Schwierzeck, +8

Nature

Lymphocyte DevelopmentImmune Cell DevelopmentAdaptive Immune SystemImmunologyImmune Regulation +12

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Nimitha R. Mathew, Francis Baumgartner, Lukas M. Braun, +126

Nature Medicine

Cell TherapyFlt3-itd-mutant Leukemia CellsImmunologyIl-15 ProductionGraft-versus-leukemia Activity +5

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice

Julia Yuen-Shan Tsang, Yakup Tanriver, Shuiping Jiang, +7

Journal of Clinical Investigation

Cell TherapyRecipient MhcGeneticsT-regulatory CellImmunology +20

Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants

Sebastian Weigang, Jonas Fuchs, Gert Zimmer, +19

Nature Communications

The Transcription Factor T-bet Is Induced by IL-15 and Thymic Agonist Selection and Controls CD8αα+ Intraepithelial Lymphocyte Development

Christoph S. N. Klose, Katharina Blatz, Yannick d’Hargues, +8

Immunity

Thymic Agonist SelectionLymphocyte DevelopmentImmune Cell DevelopmentAdaptive Immune SystemImmunology +10

An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells

Jonathan J. Powell, Emma Thomas-McKay, Vinay Thoree, +22

Nature Nanotechnology

Mucosal VaccinationIntestinal Immune CellsNanotherapeuticsAllergyMucosal Immunology +5

Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin

Liang Ye, Daniel Schnepf, Jan Becker, +7

Nature Immunology

InflammationAdaptive Immune SystemPathogenesisImmunologyInnate Immune System +6

Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues

Fabian Guendel, Michael Kofoed-Branzk, Konrad Gronke, +22

Immunity

Indefinite mouse heart allograft survival in recipient treated with CD4+CD25+ regulatory T cells with indirect allospecificity and short term immunosuppression

Julia Yuen-Shan Tsang, Yakup Tanriver, Shuiping Jiang, +4

Transplant Immunology

Heart Allograft SurvivalCell TherapyTransplantationShort Term ImmunosuppressionImmunology +9