The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Jordi Barretina, Giordano Caponigro, Nicolas Stransky, +57

Nature

Tumor BiologyPredictive ModellingDrug TargetOncologyEngineering +10

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

Justin Lamb, Emily Crawford, D. D. Peck, +17

Science

GeneticsMolecular BiologyBiological NetworkBiological Network VisualizationGene-expression Signatures +17

The landscape of somatic copy-number alteration across human cancers

Rameen Beroukhim, Craig H. Mermel, Dale Porter, +59

Nature

Somatic VariantTumor HeterogeneityMedicinePathologySomatic Copy-number Alteration +5

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

Margaret A. Shipp, Ken N. Ross, Pablo Tamayo, +17

Nature Medicine

BioinformaticsGene-expression ProfilingMachine LearningData ScienceData Mining +10

Multiclass cancer diagnosis using tumor gene expression signatures

Sridhar Ramaswamy, Pablo Tamayo, Ryan Rifkin, +12

Proceedings of the National Academy of Sciences

EngineeringDiagnosisPathologyGene Expression ProfilingTumor Biology +14

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

Yujin Hoshida, Augusto Villanueva, Masahiro Kobayashi, +25

New England Journal of Medicine

RNA-SeQC: RNA-seq metrics for quality control and process optimization

David S. DeLuca, Joshua Z. Levin, Andrey Sivachenko, +6

Bioinformatics

Autophagy promotes MHC class II presentation of peptides from intracellular source proteins

Jörn Dengjel, Oliver Schoor, Rainer Fischer, +11

Proceedings of the National Academy of Sciences

Identification of a gene causing human cytochrome <i>c</i> oxidase deficiency by integrative genomics

Vamsi K. Mootha, Kathleen A. Miller, Jakob Bunkenborg, +13

Proceedings of the National Academy of Sciences

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Glenn S. Cowley, Barbara A. Weir, Francisca Vázquez, +37

Scientific Data