Nelson V. Simwela

Validation of the protein kinase <i>Pf</i> CLK3 as a multistage cross-species malarial drug target

Mahmood M. Alam, Ana Sanchez-Azqueta, Omar Janha et al. · Science · 2019 · 63 citations · Full text

Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate <i>In Vivo</i> Susceptibility to Artemisinin and Chloroquine in Plasmodium berghei

Nelson V. Simwela, Katie R. Hughes, A. Roberts et al. · Antimicrobial Agents and Chemotherapy · 2020 · 30 citations · Full text

Plasmodium berghei K13 Mutations Mediate <i>In Vivo</i> Artemisinin Resistance That Is Reversed by Proteasome Inhibition

Nelson V. Simwela, Barbara H. Stokes, Dana Aghabi et al. · mBio · 2020 · 22 citations · Full text

Genome-wide screen of Mycobacterium tuberculosis-infected macrophages revealed GID/CTLH complex-mediated modulation of bacterial growth

Nelson V. Simwela, Luana Johnston, Paulina Pavinski Bitar et al. · Nature Communications · 2024 · 19 citations · Full text

Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance

Wenhu Zhan, Da-Qiang Li, Shubha Bevkal Subramanyaswamy et al. · Cell chemical biology · 2023 · 16 citations · Full text

Dual-pharmacophore Artezomibs Hijack, Biochemistry, Antiparasitic Agent +11