Rebecca Whiteley

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2020 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2022 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17

BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors

Jordi Bertrán-Alamillo, Ana Giménez‐Capitán, Ruth Román et al. · Molecular Cancer · 2023 · 21 citations · Full text

Life Sciences, Cancer Biology, Oncology +17

AZD4625 is a Potent and Selective Inhibitor of KRASG12C

Atanu Chakraborty, Lyndsey Hanson, David M. Robinson et al. · Molecular Cancer Therapeutics · 2022 · 10 citations · Full text

Medicine, Oncology, Pharmacology +15