Hiroshi Sakikawa

Rational design and synthesis of a novel class of active site-targeted HIV protease inhibitors containing a hydroxymethylcarbonyl isostere. Use of phenylnorstatine or allophenylnorstatine as a transition-state mimic.

Tsutomu Mimoto, Junya Imai, Shigeki Tanaka et al. · Chemical and Pharmaceutical Bulletin · 1991 · 75 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Antiviral Compound +15

Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere.

Tsutomu Mimoto, Naoko Hattori, Haruo Takaku et al. · Chemical and Pharmaceutical Bulletin · 2000 · 45 citations · Full text

Bioorganic Chemistry, Pharmacotherapy, Antiviral Drug +16

Efficient solid phase peptide synthesis on a phenacyl-resin by a methanesulfonic acid .ALPHA.-amino deprotecting procedure.

Yoshiaki Kiso, Tooru Kimura, Yoichi Fujiwara et al. · Chemical and Pharmaceutical Bulletin · 1990 · 19 citations · Full text

Several Peptides, Engineering, Biochemistry +15

A Practical Synthesis of Highly Hindered Biphenyl-2-carboxylates via Nucleophilic Aromatic Substitution of <i>tert</i>-Butyl 2-Methoxybenzoates with Aryl Grignard Reagent

Shinji Aki, Yoshikazu Haraguchi, Hiroshi Sakikawa et al. · Organic Process Research & Development · 2001 · 15 citations

Bioorganic Chemistry, Organic Chemistry, Chemistry +19