Sinead A O’Rourke

Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages

Sinead A O’Rourke, Nuno Neto, Eimear Devilly et al. · Atherosclerosis · 2022 · 42 citations · Full text

Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning

Nuno Neto, Sinead A O’Rourke, Mimi Zhang et al. · eLife · 2022 · 33 citations · Full text

Engineering, Machine Learning, Machine Learning Models +19

Macrophage metabolic profile is altered by hydroxyapatite particle size

Lianne C. Shanley, Olwyn R. Mahon, Sinead A O’Rourke et al. · Acta Biomaterialia · 2023 · 23 citations · Full text

Immunology, Macrophage Metabolic Profile, Metabolic Remodeling +19

Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis

Emilio G. Vozza, Alanna M. Kelly, Clíodhna M. Daly et al. · Cell Death Discovery · 2024 · 12 citations · Full text

Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity

Donal J Cox, Sarah A. Connolly, Cilian Ó Maoldomhnaigh et al. · eLife · 2024 · 11 citations · Full text