A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses

Irina A. Okkelman, Nuno Neto, Dmitri B. Papkovsky, +2

Redox Biology

Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis

Achilleas Floudas, Conor M. Smith, Orla Tynan, +15

Annals of the Rheumatic Diseases

Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint

Achilleas Floudas, Nuno Neto, Viviana Marzaioli, +10

JCI Insight

ImmunologyImmune RegulationCell DeathPathologyBlood Cell +24

SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration

Ema Ozaki, Luke Gibbons, Nuno Neto, +8

Life Science Alliance

Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis

Achilleas Floudas, Nuno Neto, Carl Orr, +8

Annals of the Rheumatic Diseases

Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages

Sinead A O’Rourke, Nuno Neto, Eimear Devilly, +4

Atherosclerosis

Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip

Simone Perottoni, Nuno Neto, Cesare Di Nitto, +3

Lab on a Chip

Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset

Megan M. Hanlon, Conor M. Smith, Mary Canavan, +16

Science Advances

Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning

Nuno Neto, Sinead A O’Rourke, Mimi Zhang, +3

eLife

EngineeringMachine LearningMachine Learning ModelsTissue ImagingPattern Recognition +17

Macrophage metabolic profile is altered by hydroxyapatite particle size

Lianne C. Shanley, Olwyn R. Mahon, Sinead A O’Rourke, +4

Acta Biomaterialia

ImmunologyMacrophage Metabolic ProfileMetabolic RemodelingInflammatory Macrophage PhenotypeCellular Physiology +17