Margaret L. Grapperhaus

Discovery of a Simple Picomolar Inhibitor of Cholesteryl Ester Transfer Protein

Emily J. Reinhard, Jane L. Wang, Richard C. Durley et al. · Journal of Medicinal Chemistry · 2003 · 49 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist

Xiangyang Chen, Betsy S. Pierce, Win Naing et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 38 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Discovery of<i>N</i>-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2<i>S</i>,5<i>R</i>)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2<i>H</i>-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis

Peter Ruminski, Mark A. Massa, Joseph W. Strohbach et al. · Journal of Medicinal Chemistry · 2015 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of Chiral <i>N</i>,<i>N</i>-Disubstituted Trifluoro-3-amino-2-propanols as Potent Inhibitors of Cholesteryl Ester Transfer Protein

Richard C. Durley, Margaret L. Grapperhaus, Mark A. Massa et al. · Journal of Medicinal Chemistry · 2000 · 31 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +6

Chiral <i>N</i>,<i>N</i>-Disubstituted Trifluoro-3-Amino-2-Propanols Are Potent Inhibitors of Cholesteryl Ester Transfer Protein

Richard C. Durley, Margaret L. Grapperhaus, Brian S. Hickory et al. · Journal of Medicinal Chemistry · 2002 · 27 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15