Hengmiao Cheng

Studies on the Substrate Binding Segments and Catalytic Action of Lanosterol Synthase. Affinity Labeling with Carbocations Derived from Mechanism-Based Analogs of 2,3-Oxidosqualene and Site-Directed Mutagenesis Probes

E. J. Corey, Hengmiao Cheng, C. H. Baker et al. · Journal of the American Chemical Society · 1997 · 90 citations

Molecular Biology, Chemical Biology, Enzymatic Modification +18

New Insights Regarding the Cyclization Pathway for Sterol Biosynthesis from (S)-2,3-Oxidosqualene

E. J. Corey, Scott C. Virgil, Hengmiao Cheng et al. · Journal of the American Chemical Society · 1995 · 88 citations

Engineering, Altmetric Attention Score, Secondary Metabolite +16

Methodology for the Preparation of Pure Recombinant <i>S. cerevisiae</i> Lanosterol Synthase Using a Baculovirus Expression System. Evidence That Oxirane Cleavage and A-Ring Formation Are Concerted in the Biosynthesis of Lanosterol from 2,3-Oxidosqualene

E. J. Corey, Hengmiao Cheng, C. H. Baker et al. · Journal of the American Chemical Society · 1997 · 84 citations

Engineering, -2,3-Epoxysqualene Mutase, Molecular Biology +17

Molecular Cloning of aSchizosaccharomyces pombecDNA Encoding Lanosterol Synthase and Investigation of Conserved Tryptophan Residues

E. J. Corey, Seiichi P. T. Matsuda, C. H. Baker et al. · Biochemical and Biophysical Research Communications · 1996 · 70 citations

Biosynthesis, Cellular Enzymology, Biochemistry +9

Conversion of a C20 2,3-oxidosqualene analog to tricyclic structures with a five-membered C-ring by lanosterol synthase. Further evidence for a C-ring expansion step in sterol biosynthesis

E. J. Corey, Hengmiao Cheng · Tetrahedron Letters · 1996 · 37 citations

Biosynthesis, Engineering, Heterocyclic +8