Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production

Line S. Reinert, Ahmad Rashidi, Diana Tran, +18

Journal of Clinical Investigation

Viral PathogenesisImmunologyCell DeathImmune RegulationSimplex Encephalitis +17

HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

Chiranjeevi Bodda, Line S. Reinert, Stefanie Fruhwürth, +13

The Journal of Experimental Medicine

Hsv1 MutantsViral PathogenesisImmunologyInnate ImmunityHsv1 δDub +21

TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain

Stefanie Fruhwürth, Line S. Reinert, C Oberg, +4

Science Advances

Effect of chronic kidney disease on macrophage cholesterol efflux

Sabine M. Meier, Anna Wultsch, Marianne Hollaus, +16

Life Sciences

Renal DiseaseCardiovascular DiseaseMedicineHyperlipidemiaVascular Biology +4

High-density lipoprotein endocytosis in endothelial cells

Stefanie Fruhwürth, Margit Pavelka, Robert Bittman, +4

World Journal of Biological Chemistry

Inhibition of mTOR down-regulates scavenger receptor, class B, type I (SR-BI) expression, reduces endothelial cell migration and impairs nitric oxide production

Stefanie Fruhwürth, Sigurd Krieger, Katharina Winter, +6

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Class BRapamycin TreatmentImmunologyHyperlipidemiaMtor Inhibitor Rapamycin +20

APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons

Sandra Roselli, Tuğçe Munise Şatır, Rafael Camacho, +4

Cellular and Molecular Neurobiology

<scp>ER</scp> stress induces <scp>caspase‐2‐tBID‐GSDME</scp> ‐dependent cell death in neurons lytically infected with herpes simplex virus type 2

Fanghui Ren, Ryo Narita, Ahmad Rashidi, +7

The EMBO Journal

The unfolded protein response is a negative regulator of scavenger receptor class B, type I (SR-BI) expression

Tanja Eberhart, Karin Eigner, Yüksel Filik, +3

Biochemical and Biophysical Research Communications

Negative RegulatorLipid PeroxidationImmunologyEr StressCholesterol Homeostasis +21

Scavenger receptor, Class B, Type I provides an alternative means for β-VLDL uptake independent of the LDL receptor in tissue culture

Clemens Röhrl, Stefanie Fruhwürth, Sabine M. Schreier, +7

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Molecular PharmacologyMolecular PhysiologyClass BOxysterolMedicine +7