The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: Persistent p27Kip1 induction by interfering with PI3K/Akt/FOXO3a signaling pathway

Ao Li, Jun Wang, Mingjun Wu, +2

European Journal of Pharmacology

Signal TransductionSignaling PathwayCell DivisionLiver PhysiologyAutophagy +9

Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis

Xi Li, Yan Li, Jintao Xiao, +30

Nature Communications

Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy

Ao Li, Xiaoxun Zhang, Shu Mao, +6

Phytomedicine

Glomerular DiseaseInflammationUrologyRenal FunctionAutoimmune Disease +10

Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis

Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, +15

Gastroenterology

BiochemistryBiliary TractNatural SciencesMembrane TransportGastroenterology +6

Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis

Min Liao, Junwei Liao, Jiaquan Qu, +13

Cell Death Discovery

A homozygous R148W mutation in <i>Semaphorin 7A</i> causes progressive familial intrahepatic cholestasis

Qiong Pan, Gang Luo, Jiaquan Qu, +20

EMBO Molecular Medicine

HepatologyBiliary TractGenetic DisorderLiver PhysiologyGenetics +8

Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population

Jingjing Ding, Huaizheng Liu, Xiaoxun Zhang, +9

Science Translational Medicine

Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor β-independent mechanism

Ao Li, Jingyao Zhang, Xiaoxun Zhang, +6

Scientific Reports

SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface

Nan Zhao, Xiaoxun Zhang, Jingjing Ding, +17

JCI Insight

ImmunologyPathologyFatty Liver DiseaseInflammationMetabolic Syndrome +17

Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice

Huiwen Wang, Jian Zhang, Xiaoxun Zhang, +6

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

InflammationFibrosisGastrointestinal PharmacologyLiver PhysiologyMedicine +11