Taylor K. Downs

Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation

Michael S. Schappe, Kalina Szteyn, Marta E. Stremska et al. · Immunity · 2018 · 245 citations · Full text

Inflammation, Toll-like Receptors, Signal Transduction +12

Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging

Philip V. Seegren, Logan R. Harper, Taylor K. Downs et al. · Nature Aging · 2023 · 68 citations · Full text

Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

Sean R. Cuddy, Austin R. Schinlever, Sara A. Dochnal et al. · eLife · 2020 · 56 citations · Full text

Immunology, Viral Pathogenesis, Immune Regulation +24

Efferocytosis requires periphagosomal Ca2+-signaling and TRPM7-mediated electrical activity

Michael S. Schappe, Marta E. Stremska, Gregory W. Busey et al. · Nature Communications · 2022 · 35 citations · Full text

Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing

Philip V. Seegren, Taylor K. Downs, Marta E. Stremska et al. · Cell Reports · 2020 · 29 citations · Full text