Akifumi Morimoto

Construction of Engineered Water-soluble PQQ Glucose Dehydrogenase with Improved Substrate Specificity

Koji Sode, Satoshi Igarashi, Akifumi Morimoto et al. · Biocatalysis and Biotransformation · 2002 · 28 citations

Engineering, Molecular Biology, Amino Acid Substitution +19

Hit-to-lead optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as a novel class of EP1 receptor antagonists

Masakazu Atobe, Kenji Naganuma, Masashi Kawanishi et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 20 citations · Full text

Medicinal Chemistry, Drug Target, Biochemistry +11

Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human β₃-Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects

Yasuhiro Wada, Hiromitsu Shirahashi, Taisuke Iwanami et al. · Journal of Medicinal Chemistry · 2015 · 20 citations · Full text

Molecular Pharmacology, Pre-clinical Pharmacology, Novel Indazole Derivatives +14

Discovery of 2-(1H-indazol-1-yl)-thiazole derivatives as selective EP1 receptor antagonists for treatment of overactive bladder by core structure replacement

Masakazu Atobe, Kenji Naganuma, Masashi Kawanishi et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 19 citations · Full text

Medicine, Pharmacotherapy, Core Structure Replacement +4

SAR-based optimization of 2-(1H-pyrazol-1-yl)-thiazole derivatives as highly potent EP1 receptor antagonists

Masakazu Atobe, Kenji Naganuma, Masashi Kawanishi et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 18 citations · Full text

Medicinal Chemistry, Drug Target, Biochemistry +11