Cathal P. Connern

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

Andrew P. Halestrap, Kuei-Ying Woodfield, Cathal P. Connern · Journal of Biological Chemistry · 1997 · 588 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Cyclosporin A binding in mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury

Andrew P. Halestrap, Cathal P. Connern, Elinor J. Griffiths et al. · Molecular and Cellular Biochemistry · 1997 · 348 citations

Life Sciences, Cardiology, Pharmacology +17

Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel

Cathal P. Connern, Andrew P. Halestrap · Biochemical Journal · 1994 · 249 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Purification and <i>N</i>-terminal sequencing of peptidyl-prolyl <i>cis-trans</i>-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin

Cathal P. Connern, Andrew P. Halestrap · Biochemical Journal · 1992 · 193 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Chaotropic Agents and Increased Matrix Volume Enhance Binding of Mitochondrial Cyclophilin to the Inner Mitochondrial Membrane and Sensitize the Mitochondrial Permeability Transition to [Ca²⁺]

Cathal P. Connern, Andrew P. Halestrap · Biochemistry · 1996 · 105 citations

Life Sciences, Biochemistry, Cell Biology +13