Sodium Late Current Blockers in Ischemia Reperfusion: Is the Bullet Magic?

Bruno Le Grand, Christophe Pignier, Robert Létienne, +4

Journal of Medicinal Chemistry

HypertensionHeart FailureIschemia ReperfusionCardiovascular PharmacologyPharmacotherapy +18

Evidence that ranolazine behaves as a weak β 1 - and β 2 -adrenoceptor antagonist in the rat cardiovascular system

Robert Létienne, Bruno Vié, Aline Puech, +3

Naunyn-Schmiedeberg s Archives of Pharmacology

Molecular PharmacologyMedicineVascular PharmacologyPhysiologyCardiovascular Pharmacology +8

Protease-Activated Receptor-1 Antagonist F 16618 Reduces Arterial Restenosis by Down-Regulation of Tumor Necrosis Factor α and Matrix Metalloproteinase 7 Expression, Migration, and Proliferation of Vascular Smooth Muscle Cells

Pauline Chieng-Yane, Arnaud Bocquet, Robert Létienne, +7

Journal of Pharmacology and Experimental Therapeutics

Discovery of Novel Protease Activated Receptors 1 Antagonists with Potent Antithrombotic Activity in Vivo

Michel Perez, Marie Lamothe, Catherine Maraval, +13

Journal of Medicinal Chemistry

Antiplatelet DrugsImmunologyPharmacotherapyImmunotherapyThrombin-induced Platelet Aggregation +16

F 15845 inhibits persistent sodium current in the heart and prevents angina in animal models

Bernard Vacher, Christophe Pignier, Robert Létienne, +2

British Journal of Pharmacology

Cardiac IschaemiaCardiac MuscleCardiovascular PharmacologyCardiovascular FunctionAnimal Models +16

Short‐term haemodynamic variability in the conscious areflexic rat

Robert Létienne, Christian Barrès, Catherine Cerutti, +1

The Journal of Physiology

Na⁺ Currents in Cardioprotection: Better to Be Late

Bruno Le Grand, Christophe Pignier, Robert Létienne, +6

Journal of Medicinal Chemistry

Heart FailureCardiovascular PharmacologyPharmacotherapyIschemia-induced ContractureCardiovascular Function +14

Antiplatelet and antithrombotic effect of F 16618, a new thrombin proteinase‐activated receptor‐1 (PAR1) antagonist

Monique Dumas, Florence Nadal-Wollbold, Pascale Gaussem, +7

British Journal of Pharmacology

3-(R)-[3-(2-Methoxyphenylthio-2-(S)-methylpropyl]amino-3,4-dihydro-2H-1,5-benzoxathiepine Bromhydrate (F 15845) Prevents Ischemia-Induced Heart Remodeling by Reduction of the Intracellular Na+ Overload

Bruno Vié, Sylvie Sablayrolles, Robert Létienne, +5

Journal of Pharmacology and Experimental Therapeutics

Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart

Robert Létienne, Bruno Vié, Bruno Le Grand

European Journal of Pharmacology

Cardiac MuscleChannelopathiesMedicinePhysiologySodium Channels +7