Gilda Mak

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling <i>in vitro</i> and inhibits insulin-like growth factor-I receptor–dependent tumor growth <i>in vivo</i>

Qunsheng Ji, Mark J. Mulvihill, Maryland Rosenfeld-Franklin et al. · Molecular Cancer Therapeutics · 2007 · 147 citations · Full text

Igf-ii Expression, Signal Transduction, Growth Hormone +14

Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

Mark J. Mulvihill, Qunsheng Ji, Heather Coate et al. · Bioorganic & Medicinal Chemistry · 2007 · 72 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +9

1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors

Mark J. Mulvihill, Qunsheng Ji, Doug Werner et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 32 citations · Full text

Medicinal Chemistry, Medicine, Mechanism Of Action +6

Transforming growth factor-β3 protection of epithelial cells from cycle-selective chemotherapy in vitro

E.Siobhan McCormack, Gary Borzillo, Claire Ambrosino et al. · Biochemical Pharmacology · 1997 · 31 citations

Medicine, Cycle-selective Chemotherapy, Cancer Growth +11

Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy

Meizhong Jin, Andrew Kleinberg, Andy Cooke et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 16 citations · Full text

Medicinal Chemistry, Diabetes, Pharmacology +9