Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

Malin Sandberg, Huda Al-Doujaily, Bernadette Sharps, +2

Nature

Distinct Mechanistic PhasesMedicineNatural SciencesMolecular BiologyPrion Disease +5

Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked

Malin Sandberg, Huda Al-Doujaily, Bernadette Sharps, +9

Nature Communications

Systems BiologyCreutzfeldt-jakob DiseaseClassical PrpMedicineNatural Sciences +13

A Novel Prion Disease Associated with Diarrhea and Autonomic Neuropathy

Simon Mead, Sonia Gandhi, Jon Beck, +22

New England Journal of Medicine

Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein

Malin Sandberg, Huda Al-Doujaily, Christina J. Sigurdson, +8

Journal of General Virology

Creutzfeldt-jakob DiseaseTransgenic Mouse ModelsGeneticsImmunologyMolecular Biology +21

A First Look at Duloxetine (Cymbalta(R)) in a Postmortem Laboratory

David R. Anderson, Susan D. Reed, J. Lintemoot, +4

Journal of Analytical Toxicology

New DrugTherapeutic Drug MonitoringMedicinal ChemistryPsychotropic MedicationBehavioral Pharmacology +13

Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose

Jonathan D. F. Wadsworth, Susan Joiner, Jacqueline M. Linehan, +16

The Journal of Infectious Diseases

Creutzfeldt-jakob DiseaseTransgenic Mouse ModelsPrion TransmissionGeneticsPathology +14

A systematic investigation of production of synthetic prions from recombinant prion protein

Christian Schmidt, Jérémie Fizet, Mark Batchelor, +16

Open Biology

Highly infectious prions are not directly neurotoxic

Iryna Benilova, M. Reilly, Cassandra Terry, +10

Proceedings of the National Academy of Sciences

Neurodegenerative DiseasesCreutzfeldt-jakob DiseaseInfectious PrionsMedicinePathogenesis +11

Scrapie-infected GT1-1 cells show impaired function of voltage-gated N-type calcium channels (Cav 2.2) which is ameliorated by quinacrine treatment

Malin Sandberg, Peter Wallén, Martin A. Wikström, +1

Neurobiology of Disease

Quinacrine TreatmentSignal TransductionCav 2.2MedicinePathogenesis +7

N-terminal Domain of Prion Protein Directs Its Oligomeric Association

Clare R. Trevitt, Laszlo L. P. Hosszu, Mark Batchelor, +13

Journal of Biological Chemistry

Protein FunctionMolecular BiologyPrion DiseaseOligomeric AssociationProtein Genetics