Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

Jun Wei, Lingyun Long, Wenting Zheng, +14

Nature

Cancer TherapyCancer ImmunosurveillanceNovel TherapyImmunologyImmune Checkpoint Inhibitor +7

The genetic basis and cell of origin of mixed phenotype acute leukaemia

Thomas Alexander, Zhaohui Gu, Ilaria Iacobucci, +59

Nature

Hematological MalignancyMixed-phenotype Acute LeukemiaGeneticsMalignant Blood DisorderImmunology +6

Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

Jon D. Larson, Lawryn H. Kasper, Barbara S. Paugh, +23

Cancer Cell

ChromatinNeuro-oncologyMolecular NeuroscienceGliomaBivalent Gene Expression +9

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

Jinghui Zhang, Kelly McCastlain, Hiroki Yoshihara, +73

Nature Genetics

Hematological MalignancyMixed-phenotype Acute LeukemiaHematologyAcute Lymphoblastic LeukemiaMedicine +2

Orthotopic patient-derived xenografts of paediatric solid tumours

Elizabeth Stewart, Sara M. Federico, Xiang Chen, +22

Nature

MedicineOrthotopic Patient-derived XenograftsRadiopharmaceutical TherapyOncologyRadiation Oncology +1

The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis

Issam Aldiri, Beisi Xu, Lu Wang, +18

Neuron

Dynamic Epigenetic LandscapeChromatinPhotoreceptor CellDevelopmental BiologyRetina +9

<i>MYC</i> Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification

Mark W. Zimmerman, Yu Liu, Shuning He, +12

Cancer Discovery

Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity

Peer W. F. Karmaus, Xiang Chen, Seon Ah Lim, +14

Nature

Lineage PlasticityCell LineageDevelopmental BiologyMedicineStem Cell Research +7

Enhancer Hijacking Drives Oncogenic <i>BCL11B</i> Expression in Lineage-Ambiguous Stem Cell Leukemia

Lindsey E. Montefiori, Sonja Bendig, Zhaohui Gu, +49

Cancer Discovery

Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses

Elizabeth Stewart, Justina McEvoy, Hong Wang, +35

Cancer Cell

Systems BiologyFunctional GenomicsEngineeringTumor HeterogeneityProteomic Analyses +11