High IFN-γ and low SLPI mark severe asthma in mice and humans

Mahesh Raundhal, Christina Morse, Anupriya Khare, +10

Journal of Clinical Investigation

AsthmaInflammatory Lung DiseaseLung InflammationImmunodeficienciesImmunology +23

Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma

Nandini Krishnamoorthy, Anupriya Khare, Timothy B. Oriss, +8

Nature Medicine

AsthmaEarly InfectionAllergyAdaptive Immune SystemRespiratory Diseases +4

STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia

Stephanie Poe, Meenakshi Arora, Timothy B. Oriss, +9

Mucosal Immunology

InflammationLung InflammationMedicineImmunologyRespiratory Infection +7

Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses

Anita Garg Mangla, Anupriya Khare, Vineeth Varanasi, +6

Blood

TNF-α from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection

Mingjian Fei, Shikha Bhatia, Timothy B. Oriss, +11

Proceedings of the National Academy of Sciences

Cutting Edge: Inhaled Antigen Upregulates Retinaldehyde Dehydrogenase in Lung CD103+ but Not Plasmacytoid Dendritic Cells To Induce Foxp3 De Novo in CD4+ T Cells and Promote Airway Tolerance

Anupriya Khare, Nandini Krishnamoorthy, Timothy B. Oriss, +3

The Journal of Immunology

Inflammatory Lung DiseaseLung InflammationDendritic CellT-regulatory CellImmune Regulation +19

The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia

Krishnendu Chakraborty, Mahesh Raundhal, Bill B. Chen, +12

Nature Communications

Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells

Elizabeth A. Oczypok, Pavle S. Milutinovic, John F. Alcorn, +7

Journal of Allergy and Clinical Immunology

InflammationAsthmaCytokineGroup 2Allergy +10

Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury

Ya-Juan Zhao, Z. Xiong, Elizabeth Lechner, +16

Mucosal Immunology

Acute Lung InjuryInflammationCytokineInflammatory Lung DiseaseLung Inflammation +11

Cutting Edge: Dual Function of PPARγ in CD11c+ Cells Ensures Immune Tolerance in the Airways

Anupriya Khare, Krishnendu Chakraborty, Mahesh Raundhal, +2

The Journal of Immunology