High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails

Brian R. Shy, Vivasvan S. Vykunta, Alvin Ha, +20

Nature Biotechnology

Primary CellsGenome InstabilityHigh-yield Genome EngineeringEngineeringSmall-molecule Cocktails +9

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance

Ian Ferguson, Bonell Patiño-Escobar, Sami T. Tuomivaara, +26

Nature Communications

Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies

Daniel B. Goodman, Camillia S. Azimi, Kendall Kearns, +13

Science Translational Medicine

An evolved AAV variant enables efficient genetic engineering of murine T cells

William A. Nyberg, Jonathan Ark, Angela To, +15

Cell

Biallelic deletion of 1p32 defines ultra-high-risk myeloma, but monoallelic del(1p32) remains a strong prognostic factor

Anaïs Schavgoulidze, Alexis Talbot, Aurore Perrot, +24

Blood

Increased Infection Rate After Preemptive Rituximab Treatment for Epstein-Barr Virus Reactivation After Allogeneic Hematopoietic Stem-Cell Transplantation

Anna D. Petropoulou, Raphaël Porcher, Régis Peffault de Latour, +11

Transplantation

The long non-coding RNA CRNDE regulates growth of multiple myeloma cells via an effect on IL6 signalling

Antoine David, Simone Zocchi, Alexis Talbot, +8

Leukemia

ImmunologyMyelopoiesisLong Non-coding RnaMultiple Myeloma CellsGene Expression +5

NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia

Matthew T. Witkowski, Soobeom Lee, Eric Wang, +17

Nature Immunology

Alternative Mrna PolyadenylationHematological MalignancyMixed-phenotype Acute LeukemiaImmunologyHematology +5

Teclistamab in relapsed or refractory AL amyloidosis: a multinational retrospective case series

Nathalie Forgeard, Dikélélé Elessa, Alexander Carpinteiro, +17

Blood

Plasma cell-directed therapies in monoclonal gammopathy-associated scleromyxedema

T. Mahévas, Bertrand Arnulf, Jean‐David Bouaziz, +43

Blood