Timothy A. Troppoli

Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice

Natalie Hesselgrave, Timothy A. Troppoli, Andreas B. Wulff et al. · Proceedings of the National Academy of Sciences · 2021 · 362 citations · Full text

Neuropsychology, Psychotropic Medication, Neurotransmitter +21

Antidepressant-relevant concentrations of the ketamine metabolite (2 <i>R</i> ,6 <i>R</i> )-hydroxynorketamine do not block NMDA receptor function

Eric W. Lumsden, Timothy A. Troppoli, Scott J. Myers et al. · Proceedings of the National Academy of Sciences · 2019 · 151 citations · Full text

(<i>R</i>)‐Ketamine exerts antidepressant actions partly via conversion to (<i>2R,6R</i>)‐hydroxynorketamine, while causing adverse effects at sub‐anaesthetic doses

Panos Zanos, Jaclyn N. Highland, Xin Liu et al. · British Journal of Pharmacology · 2019 · 81 citations · Full text

Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit–Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice

Timothy A. Troppoli, Panos Zanos, Polymnia Georgiou et al. · Biological Psychiatry · 2021 · 27 citations · Full text

Synaptic Plasticity, Molecular Neuroscience, Negative Allosteric Modulation +13