HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis

Yoshiteru Miyauchi, Yuiko Sato, Tami Kobayashi, +15

Proceedings of the National Academy of Sciences

Osteoclast stimulatory transmembrane protein and dendritic cell–specific transmembrane protein cooperatively modulate cell–cell fusion to form osteoclasts and foreign body giant cells

Hiroya Miyamoto, Takayuki Suzuki, Yoshiteru Miyauchi, +18

Journal of Bone and Mineral Research

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

Kana Miyamoto, Shigeyuki Yoshida, Miyuri Kawasumi, +17

The Journal of Experimental Medicine

Specific Bone MarrowBone Morphogenic ProteinMedicineStem Cell MobilizationHspc Mobilization +11

Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation

Hao Wu, Syoichi Tashiro, Tomoka Hasegawa, +14

Journal of Biological Chemistry

Igf1 Protein Down-regulationPeripheral NervesCellular PhysiologyInsulin SignalingMetabolic Syndrome +15

Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis

Hiroko Hoshi, Hao Wu, Yoshinari Fujita, +25

Journal of Bone and Mineral Research

Stat3 as a potential therapeutic target for rheumatoid arthritis

Takatsugu Oike, Yuiko Sato, Tami Kobayashi, +10

Scientific Reports

Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy

Toshimi Tando, Akiyoshi Hirayama, Mitsuru Furukawa, +17

Journal of Biological Chemistry

Muscle PhysiologyMuscle FunctionMolecular PhysiologySignal TransductionSmad2/3 Proteins +13

Elevation of pro-inflammatory cytokine levels following anti-resorptive drug treatment is required for osteonecrosis development in infectious osteomyelitis

Mayu Morita, Ryotaro Iwasaki, Yuiko Sato, +14

Scientific Reports

Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors

Hiroya Kanagawa, Ritsuko Masuyama, Mayu Morita, +14

Journal of Bone and Mineral Metabolism

Orthopaedic SurgeryBone Morphogenic ProteinBone RepairOsteoarthritisRankl-induced Calcium Influx +10

An Essential Role for STAT6-STAT1 Protein Signaling in Promoting Macrophage Cell-Cell Fusion

Hiroya Miyamoto, Eri Katsuyama, Yoshiteru Miyauchi, +14

Journal of Biological Chemistry

InflammationCytokineSignal TransductionEssential RoleSignaling Pathway +9