Heat Shock Protein 90: Inhibitors in Clinical Trials

Marco A. Biamonte, Ryan Van de Water, Joseph W. Arndt, +3

Journal of Medicinal Chemistry

ImmunologyAltmetric Attention ScoreMolecular BiologyThermal TherapyPharmacotherapy +14

Selective, Tight-Binding Inhibitors of Integrin α4β1 That Inhibit Allergic Airway Responses

Ko‐Chung Lin, Humayun S. Ateeq, Sherry H. Hsiung, +14

Journal of Medicinal Chemistry

Inflammatory Lung DiseaseLung InflammationApoptosis InhibitionImmunologyPeptide Science +19

Successful shape-Based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)

Juswinder Singh, Claudio Chuaqui, P. Ann Boriack‐Sjodin, +11

Bioorganic & Medicinal Chemistry Letters

Virtual ScreeningTgfβ Receptor KinaseEngineeringPotent InhibitorReceptor Tyrosine Kinase +6

A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth <i>In vivo</i> and Prevents Tumor Recurrence after Surgical Resection

Eiji Suzuki, Samuel Kim, Hung Kam Cheung, +8

Cancer Research

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery

Daniel A. Erlanson, Joseph W. Arndt, Mark T. Cancilla, +23

Bioorganic & Medicinal Chemistry Letters

Molecular DockingFragment-based Drug DiscoveryDrug TargetBiochemistrySelective Pdk1 Inhibitor +4

SM16, an Orally Active TGF-β Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model

Kai Fu, Michael J. Corbley, Lihong Sun, +24

Arteriosclerosis Thrombosis and Vascular Biology

The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

Kendra Garrison, Tobias Hahn, Wen‐Cherng Lee, +3

Cancer Immunology Immunotherapy

Inhibitor Sm16MedicineImmunologyAgonistic Ox40 AntibodySmall Molecule Tgf-β +4

Identification of Potent and Novel α4β1 Antagonists Using in Silico Screening

Juswinder Singh, Herman van Vlijmen, Yusheng Liao, +8

Journal of Medicinal Chemistry

Drug TargetImmunologyPharmacotherapyRheumatoid ArthritisProtein Function +15

Pyrazolone based TGFβR1 kinase inhibitors

Kevin M. Guckian, Mary Beth Carter, Edward Yin-Shiang Lin, +8

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicineRational Drug DesignPharmacotherapyAnti-cancer Agent +4

An Abiotic Strategy for the Enantioselective Synthesis of Erythromycin B

Paul J. Hergenrother, Anne Hodgson, Andrew S. Judd, +2

Angewandte Chemie International Edition

Sweet SuccessBiosynthesisBioorganic ChemistryBiochemistryMedicine +13