Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

Robert Wirka, Dhananjay Wagh, David T. Paik, +18

Nature Medicine

Signal TransductionAtheroprotective RolesSignaling PathwaySkeletal MuscleMedicine +7

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

Clint L. Miller, Milos Pjanic, Ting Wang, +17

Nature Communications

Single-cell multi-cohort dissection of the schizophrenia transcriptome

W. Brad Ruzicka, Shahin Mohammadi, John F. Fullard, +213

Science

NeuropsychologyGeneticsSchizophrenia TranscriptomeSocial SciencesSingle-cell Dissection +16

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap

Sylvia Nürnberg, Karen Cheng, Azad Raiesdana, +18

PLoS Genetics

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci

Boxiang Liu, Milos Pjanic, Ting Wang, +11

The American Journal of Human Genetics

Vascular DiseaseMolecular PhysiologyGenetic DeterminantCardiovascular DiseaseVascular Adaptation +9

Coronary Disease-Associated Gene <i>TCF21</i> Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway

Manabu Nagao, Qing Lyu, Quanyi Zhao, +8

Circulation Research

Environment-Sensing Aryl Hydrocarbon Receptor Inhibits the Chondrogenic Fate of Modulated Smooth Muscle Cells in Atherosclerotic Lesions

Juyong Brian Kim, Quanyi Zhao, Trieu Nguyen, +7

Circulation

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells

Juyong Brian Kim, Milos Pjanic, Trieu Nguyen, +10

PLoS Genetics

ImmunologyTcf21 ExpressionGene CharacterizationInflammationSignaling Pathway +18

A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex

Louise A. Huuki-Myers, Abby Spangler, Nicholas J. Eagles, +232

Science

NeurogenomicsHuman Prefrontal CortexBrain MappingBrain OrganizationSpatial Omics +18

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk

Dharini Iyer, Quanyi Zhao, Robert Wirka, +9

PLoS Genetics

Vascular DiseaseGeneticsGene CharacterizationDisease Gene IdentificationInteractive Genetic Programs +24