Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis

Haifeng Shao, Lindsay C. Burrage, David S. Sinasac, +11

Proceedings of the National Academy of Sciences

Phenotypic VariationGeneticsGenetic FoundationPervasive EpistasisEpistasis +16

Lack of CFTR in Skeletal Muscle Predisposes to Muscle Wasting and Diaphragm Muscle Pump Failure in Cystic Fibrosis Mice

Maziar Divangahi, Haouaria Balghi, Gawiyou Danialou, +8

PLoS Genetics

Enzymatic Activity of Lysosomal Carboxypeptidase (Cathepsin) A Is Required for Proper Elastic Fiber Formation and Inactivation of Endothelin-1

Volkan Seyrantepe, Aleksander Hinek, Junzheng Peng, +9

Circulation

Effects of Chronic Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants on the Reproductive and Thyroid System in Adult Male Rats

Sheila Ernest, Michael G. Wade, Claudia Lalancette, +4

Toxicological Sciences

Hair as a Biomarker of Systemic Exposure to Polybrominated Diphenyl Ethers

Shirley Poon, Michael G. Wade, Katarina Aleksa, +11

Environmental Science & Technology

Exposure AssessmentDermatologyPbde MixtureEnvironmental ChemistryEnvironmental Health +18

Exposure to an environmentally relevant mixture of brominated flame retardants affects fetal development in Sprague-Dawley rats

R Berger, Pavine Lefèvre, Sheila Ernest, +6

Toxicology

Exposure of Female Rats to an Environmentally Relevant Mixture of Brominated Flame Retardants Targets the Ovary, Affecting Folliculogenesis and Steroidogenesis1

Pavine Lefèvre, R Berger, Sheila Ernest, +5

Biology of Reproduction

FertilityReproductive HealthFemale Reproductive FunctionReproductive BiologyBrominated Flame Retardants +20

Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17

Carrie A. Millward, Lindsay C. Burrage, Haifeng Shao, +9

Mammalian Genome

ObesityMetabolic SyndromeMetabolic DisorderGeneticsPhysiology +7

Homocysteine levels in A/J and C57BL/6J mice: genetic, diet, gender, and parental effects

Sheila Ernest, Angela Hosack, William E. O’Brien, +2

Physiological Genomics

Understanding Homocysteine HomeostasisGeneticsGenetic EpidemiologyHuman PolymorphismOxidative Stress +18

In utero exposure to venlafaxine, a serotonin–norepinephrine reuptake inhibitor, increases cardiac anomalies and alters placental and heart serotonin signaling in the rat

Chunwei Huang, Sheila Ernest, Anick Bérard, +2

Birth Defects Research Part A Clinical and Molecular Teratology