Melanie Mediavilla-Varela

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

Limo Chen, Don L. Gibbons, Sangeeta Goswami et al. · Nature Communications · 2014 · 995 citations · Full text

Medicine, Cancer Biology, Oncology +16

Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75

Melanie Mediavilla-Varela, Fabio J. Pacheco, Frankis Almaguel et al. · Molecular Cancer · 2009 · 135 citations · Full text

Medicine, Oncology, Pharmacology +17

The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts

Melanie Mediavilla-Varela, Kingsley A. Boateng, David Noyes et al. · BMC Cancer · 2016 · 115 citations · Full text

Medicine, Oncology, Pharmacology +15

Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth

Melanie Mediavilla-Varela, Kimberly A. Luddy, David Noyes et al. · Cancer Biology & Therapy · 2013 · 99 citations · Full text

Medicine, Oncology, Pharmacology +17

A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment

Melanie Mediavilla-Varela, Julio Castro, Alberto Chiappori et al. · Neoplasia · 2017 · 89 citations · Full text

Medicine, Immunology, Oncology +17