Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses

Valeria Francesconi, Elena Cichero, Silvia Schenone, +2

Molecules

Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1

Simona Capponi, Thomas Geuens, Alessandro Geroldi, +12

Human Mutation

Neurodegenerative DiseasesMolecular ChaperonesAmyotrophic Lateral SclerosisCandidate Gene Hspb1Hspb1 Mutations +12

Insights into the Structure and Pharmacology of the Human Trace Amine‐Associated Receptor 1 (<i>h</i>TAAR1): Homology Modelling and Docking Studies

Elena Cichero, Stefano Espinoza, Raul R. Gainetdinov, +2

Chemical Biology & Drug Design

Drug TargetMolecular BiologyHtaar1 Key ResiduesSynaptic SignalingMolecular Pharmacology +22

Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (<i>m</i>TAAR1) Agonists

Grazia Chiellini, Giulia Nesi, Maria Digiacomo, +12

Journal of Medicinal Chemistry

PharmacotherapyExperimental PharmacologyMolecular PharmacologyMedicinal ChemistryTaar1 Activation +15

Novel biguanide-based derivatives scouted as TAAR1 agonists: Synthesis, biological evaluation, ADME prediction and molecular docking studies

Michele Tonelli, Stefano Espinoza, Raul R. Gainetdinov, +1

European Journal of Medicinal Chemistry

Molecular DockingMedicinal ChemistryDrug TargetBiochemistryNovel Biguanide-based Derivatives +11

Further Insights Into the Pharmacology of the Human Trace Amine‐Associated Receptors: Discovery of Novel Ligands for <scp>TAAR</scp>1 by a Virtual Screening Approach

Elena Cichero, Stefano Espinoza, Silvia Franchini, +4

Chemical Biology & Drug Design

Drug TargetFurther InsightsPsychotropic MedicationPharmacotherapySelective Taar1 Ligands +21

Synthesis, Biological Evaluation, and Docking Studies of Tetrahydrofuran- Cyclopentanone- and Cyclopentanol-Based Ligands Acting at Adrenergic α₁- and Serotonine 5-HT_1AReceptors

Adolfo Prandi, Silvia Franchini, Leda Ivanova Manasieva, +7

Journal of Medicinal Chemistry

New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment

Chiara Brullo, Roberta Ricciarelli, Jos Prickaerts, +17

European Journal of Medicinal Chemistry

Medicinal ChemistryAlzheimer's DiseaseStructural DevelopmentBiochemistryMedicine +9

Magnolol and Luteolin Inhibition of α-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies

Francine Medjiofack Djeujo, Eugenio Ragazzi, Miriana Urettini, +4

Pharmaceuticals

Synthesis and structure–activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis

Emanuela Pesce, Marta Bellotti, Nara Liessi, +11

European Journal of Medicinal Chemistry

Aminoarylthiazole DerivativesMedicinal ChemistryChloride Transport DefectBiochemistryNatural Sciences +6