Brenda L. Palucki

Design and Pharmacology of <i>N</i>-[(3<i>R</i>)-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1<i>R</i>)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1<i>H</i>-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (<b>1</b>), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist

Iyassu K. Sebhat, William J. Martin, Zhixiong Ye et al. · Journal of Medicinal Chemistry · 2002 · 190 citations · Full text

Erectile Dysfunction, Food Intake, Peptide Science +21

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

Brenda L. Palucki, Min K. Park, Ravi P. Nargund et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 42 citations · Full text

Medicinal Chemistry, Drug Target, Functional Selectivity +8

Metabolic Activation of a 1,3-Disubstituted Piperazine Derivative:  Evidence for a Novel Ring Contraction to an Imidazoline

George A. Doss, Randall R. Miller, Zhoupeng Zhang et al. · Chemical Research in Toxicology · 2005 · 39 citations

Medicinal Chemistry, Bioorganic Chemistry, Heterocyclic +15

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

Zhixiong Ye, Liangqin Guo, Khaled J. Barakat et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 37 citations · Full text

Medicinal Chemistry, Biochemistry, Functional Selectivity +9

Spiro(indoline-3,4′-piperidine) growth hormone secretagogues as ghrelin mimetics

Brenda L. Palucki, Scott D. Feighner, Sheng-Shung Pong et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 36 citations · Full text

Growth Hormone, Medicine, Physiology +3