A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

Vladimir Joukov, Katri Pajusola, Arja Kaipainen, +6

The EMBO Journal

AngiogenesisReceptor Tyrosine KinaseImmunologyEndothelial DysfunctionVascular Biology +7

Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

Berit Olofsson, Katri Pajusola, Arja Kaipainen, +7

Proceedings of the National Academy of Sciences

Placenta Growth FactorAngiogenesisDevelopmental BiologyEndothelial CellsBone Morphogenic Protein +12

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

Olli Saksela, David Moscatelli, Andreas Sommer, +1

The Journal of Cell Biology

Tissue EngineeringImmunologyGlycobiologyCellular PhysiologyInflammation +21

Proteolytic processing regulates receptor specificity and activity of VEGF-C

Vladimir Joukov, Tarja Sorsa, Vijay Kumar, +6

The EMBO Journal

Proteolytic Processing RegulatesSignal TransductionReceptor Tyrosine KinaseVascular BiologyCell Growth +3

Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.

Liisa Pertovaara, Arja Kaipainen, Tuija Mustonen, +4

Journal of Biological Chemistry

Endothelial CellsGrowth Factor-betaCellular PhysiologyAngiogenesisGrowth Factor Beta +14

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

Olli Saksela, Daniel B. Rifkin

The Journal of Cell Biology

Hspg SpeciesEndothelial CellsGlycobiologyCell CultureCulture Medium +17

Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.

Marikki Laiho, Olli Saksela, P.A. Andreasen, +1

The Journal of Cell Biology

Lung InflammationImmunologyPathologyGrowth Factor-betaTgf Beta +19

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells.

Olli Saksela, David Moscatelli, Daniel B. Rifkin

The Journal of Cell Biology

Tgf BetaCellular PhysiologyAngiogenesisGrowth Factor BetaFibroblast Growth Factor +16

Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells

J Pöllänen, Olli Saksela, E‐M. Salonen, +4

The Journal of Cell Biology

Cell AdhesionImmunologyContact AreasPathologyCell Culture +16

Transforming growth factor-beta induction of type-1 plasminogen activator inhibitor. Pericellular deposition and sensitivity to exogenous urokinase.

Marikki Laiho, Olli Saksela, Jorma Keski‐Oja

Journal of Biological Chemistry

Human GrowthTgf BetaGrowth Factor-betaCell ProliferationCell Growth +17