Guido Scutari

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

Alberto Bindoli, Maria Pia Rigobello, Guido Scutari et al. · Coordination Chemistry Reviews · 2009 · 577 citations · Full text

Gold Compounds, Phytoalexin, Medicinal Chemistry +12

Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells

C. Marzano, Valentina Gandin, Alessandra Folda et al. · Free Radical Biology and Medicine · 2006 · 411 citations

Reductive Stress, Auranofin Induces Apoptosis, Medicine +10

Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions

Maria Pia Rigobello, Luigi Messori, G. Marcon et al. · Journal of Inorganic Biochemistry · 2004 · 206 citations

Reductive Stress, Mitochondrial Function, Biochemistry +8

Induction of mitochondrial permeability transition by auranofin, a Gold(I)‐phosphine derivative

Maria Pia Rigobello, Guido Scutari, Rita Boscolo et al. · British Journal of Pharmacology · 2002 · 178 citations · Full text

Lipid Peroxidation, Mitochondrial Permeability Transition, Redox Biology +18

Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c

Maria Pia Rigobello, Guido Scutari, Alessandra Folda et al. · Biochemical Pharmacology · 2003 · 158 citations

Chemical Biology, Reductive Stress, Permeability Transition +11