Integrative approaches for large-scale transcriptome-wide association studies

Alexander Gusev, Arthur Ko, Huwenbo Shi, +22

Nature Genetics

Functional GenomicsGeneticsMultiomicsTranscriptomics TechnologyOmics +6

Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data

Huwenbo Shi, Gleb Kichaev, Bogdan Paşaniuc

The American Journal of Human Genetics

Genome-wide Association StudyGenetic AnalysisGenotype-phenotype AssociationSummary Association DataGenetics +9

Probabilistic fine-mapping of transcriptome-wide association studies

Nicholas Mancuso, Malika Freund, Ruth Johnson, +4

Nature Genetics

Genome-wide Association StudyProbabilistic Fine-mappingGeneticsStatistical GeneticsTranscriptomics Technology +5

Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits

Huwenbo Shi, Nicholas Mancuso, Sarah Spendlove, +1

The American Journal of Human Genetics

BiologyShared Genetic ArchitectureLinkage DisequilibriumComplex Trait GeneticsGenotype-phenotype Association +10

Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank

Zhaozhong Zhu, Yanjun Guo, Huwenbo Shi, +14

Journal of Allergy and Clinical Immunology

ObesityMetabolic SyndromeAsthmaGenetic DeterminantGenome-wide Association Study +10

Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits

Nicholas Mancuso, Huwenbo Shi, Pagé C. Goddard, +3

The American Journal of Human Genetics

Genome-wide Association StudyGenetic AnalysisFunctional GenomicsGenotype-phenotype AssociationGenetics +11

A Bayesian framework for multiple trait colocalization from summary association statistics

Claudia Giambartolomei, Jimmy Zhenli Liu, Wen Zhang, +7

Bioinformatics

Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores

Omer Weissbrod, Masahiro Kanai, Huwenbo Shi, +4

Nature Genetics

Genotype-phenotype AssociationPolygenic RiskGenetic EpidemiologyDisease MappingPolygenic Risk Scores +5

Fast and accurate imputation of summary statistics enhances evidence of functional enrichment

Bogdan Paşaniuc, Noah Zaitlen, Huwenbo Shi, +6

Bioinformatics

Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity

Steven Gazal, Omer Weissbrod, Farhad Hormozdiari, +10

Nature Genetics

Genome-wide Association StudyMedicineGeneticsGenetic EpidemiologyPathology +11