Naofumi Umigai

Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity

Mika Yamauchi, Kazuhiro Tsuruma, Shunsuke Imai et al. · European Journal of Pharmacology · 2010 · 153 citations

Ganglion Cell, Ocular Disease, Signal Transduction +11

Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain

Fumihiko Yoshino, Ayaka Yoshida, Naofumi Umigai et al. · Journal of Clinical Biochemistry and Nutrition · 2011 · 114 citations · Full text

Hypertension, Lipid Peroxidation, Reactive Oxygen Species +25

Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice

Fumiya Ishizuka, Masamitsu Shimazawa, Naofumi Umigai et al. · European Journal of Pharmacology · 2013 · 109 citations

Ocular Disease, Retina, Photoreceptor Cell +7

The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration

Naofumi Umigai, Katsuyuki MURAKAMI, M.V. Ulit et al. · Phytomedicine · 2010 · 107 citations

Pharmacological Study, Pharmacokinetic Profile, Pharmacology +5

Effect of crocetin from Gardenia Jasminoides Ellis on sleep: A pilot study

Hirohiko Kuratsune, Naofumi Umigai, R. Takeno et al. · Phytomedicine · 2010 · 81 citations

Sleep Disorders, Sleep Medicine, Sleep +7