Chang Kai Soh

Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma

Dizhong Chen, Chang Kai Soh, Wei Huang Goh et al. · Journal of Medicinal Chemistry · 2018 · 74 citations · Full text

Medicinal Chemistry, Oncology, Hepatology +15

Structure and Ligand-Based Design of mTOR and PI3-Kinase Inhibitors Leading to the Clinical Candidates VS-5584 (SB2343) and SB2602

Anders Poulsen, Harish Nagaraj, Angeline Lee et al. · Journal of Chemical Information and Modeling · 2014 · 29 citations

Phenol Headgroup, Pharmacotherapy, Cancer Biology +21

Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors

Anders Poulsen, Meredith Williams, Harish Nagaraj et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 20 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Mtor Inhibitors +4

Synthesis and biological evaluation of 6-phenylpurine linked hydroxamates as novel histone deacetylase inhibitors

Dizhong Chen, Chang Kai Soh, Wei Huang Goh et al. · Bioorganic Chemistry · 2020 · 18 citations

Biochemistry, Medicine, Biological Evaluation +6

Structure-based design of PDK1 inhibitors

Anders Poulsen, Stéphanie Blanchard, Chang Kai Soh et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 12 citations · Full text

Medicinal Chemistry, Drug Design, Medicine +8