Meredith Williams

Discovery of the Macrocycle 11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma

Anthony D. William, Angeline C.-H. Lee, Stéphanie Blanchard et al. · Journal of Medicinal Chemistry · 2011 · 194 citations · Full text

Janus Kinase 2, Pharmacotherapy, Tumor Biology +19

Interaction of tau protein with the dynactin complex

Enrico Magnani, Juan Fan, Laura Gasparini et al. · The EMBO Journal · 2007 · 176 citations · Full text

Protein Function, Protein Assembly, Protein Folding +6

A generic approach for the catalytic reduction of nitriles

Stephen Caddick, Duncan B. Judd, Alexandra K. de K. Lewis et al. · Tetrahedron · 2003 · 151 citations

Chemical Engineering, Engineering, Generic Approach +4

Discovery of Kinase Spectrum Selective Macrocycle (16<i>E</i>)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the Treatment of Cancer

Anthony D. William, Angeline C.-H. Lee, Kee Chuan Goh et al. · Journal of Medicinal Chemistry · 2011 · 99 citations · Full text

Immunology, Janus Kinase 2, Oral Efficacy +17

An improved synthesis of bis(1,3-di-N-tert-butylimidazol-2-ylidene)palladium(0) and its use in C–C and C–N coupling reactions

Stephen Caddick, F. Geoffrey N. Cloke, G.K.B. Clentsmith et al. · Journal of Organometallic Chemistry · 2001 · 95 citations

Cross-coupling Reaction, Improved Synthesis, Organometallic Catalysis +3