The ω-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of β-catenin complex, inhibiting COX-2 through repressing NF-κB, and inducing 15-prostaglandin dehydrogenase

Young‐Min Han, Migyeung Jeong, Jongmin Park, +5

Oncotarget

Docosahexaenoic AcidChemoprevention StrategyGastrointestinal PharmacologyImmunologyPathology +24

Intratumoral immunotherapy using a TLR2/3 agonist, L-pampo, induces robust antitumor immune responses and enhances immune checkpoint blockade

Won Suk Lee, Dong Sung Kim, Jeong Hun Kim, +9

Journal for ImmunoTherapy of Cancer

PLGA Microspheres Containing Hydrophobically Modified Magnesium Hydroxide Particles for Acid Neutralization-Mediated Anti-Inflammation

Joon-Kyu Kim, Eun‐Jin Go, Kyoung‐Won Ko, +4

Tissue Engineering and Regenerative Medicine

NanomedicineEngineeringAcid Neutralization-mediated Anti-inflammationMicro-encapsulationMicroemulsion +2

Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition

Napapan Kangwan, Yoon Jae Kim, Young Min Han, +4

Oncotarget

Endogenous conversion of ω-6 to ω-3 polyunsaturated fatty acids in<i>fat</i>-1 mice attenuated intestinal polyposis by either inhibiting COX-2/β-catenin signaling or activating 15-PGDH/IL-18

Young‐Min Han, Jongmin Park, Ji-Young Cha, +3

International Journal of Cancer

Intestinal PolyposisGastrointestinal PharmacologyPolyp NumberImmunologyPathology +16

Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer

Won Suk Lee, Seung Joon Lee, Hye Jin Lee, +9

Nature Communications

Mitigation of indomethacin-induced gastrointestinal damages in fat-1 transgenic mice via gate-keeper action of ω-3-polyunsaturated fatty acids

Young‐Min Han, Jongmin Park, Jing X. Kang, +5

Scientific Reports

Systemic Delivery of a STING Agonist‐Loaded Positively Charged Liposome Selectively Targets Tumor Immune Microenvironment and Suppresses Tumor Angiogenesis

Eun‐Jin Go, Hannah Yang, Wooram Park, +7

Small

ImmunologyExtracellular MicrovesiclesBiomedical EngineeringInterferon GenesSting Agonist +15

Suppressed <i>Helicobacter pylori</i>-associated gastric tumorigenesis in <i>Fat-1</i> transgenic mice producing endogenous ω-3 polyunsaturated fatty acids

Young‐Min Han, Kyung‐Jo Kim, Migyeung Jeong, +5

Oncotarget

NutritionImmunologyGastroenterologyPathologyGastrointestinal Oncology +14