Michael C. Byrns

An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies

Michael C. Byrns, Stephan Steckelbroeck, T.M. Penning · Biochemical Pharmacology · 2007 · 136 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Prostaglandin F Synthase +12

Characterization of Nucleoside Adducts of <i>cis</i>-2-Butene-1,4-dial, a Reactive Metabolite of Furan

Michael C. Byrns, Daniel P. Predecki, Lisa A. Peterson · Chemical Research in Toxicology · 2002 · 112 citations

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

Michael C. Byrns, Ling Duan, Seon Hwa Lee et al. · The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 109 citations · Full text

Breast Oncology, Prostaglandin Metabolism, Aldo-keto Reductase 1C3 +8

Development of Potent and Selective Inhibitors of Aldo–Keto Reductase 1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase) Based on<i>N</i>-Phenyl-Aminobenzoates and Their Structure–Activity Relationships

Adegoke O. Adeniji, Barry M. Twenter, Michael C. Byrns et al. · Journal of Medicinal Chemistry · 2012 · 104 citations · Full text

Detection of DNA Adducts Derived from the Reactive Metabolite of Furan, <i>cis-</i>2-Butene-1,4-dial

Michael C. Byrns, Choua C. Vu, Jonathan W. Neidigh et al. · Chemical Research in Toxicology · 2006 · 102 citations · Full text

Dna Adducts Derived, Dna Analysis, Molecular Biology +18