Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743

Daniele G. Soares, Alexandre E. Escargueil, Virginie Poindessous, +5

Proceedings of the National Academy of Sciences

Dna DamageApoptosisImmunologyMolecular BiologyCell Death +14

Irofulven Cytotoxicity Depends on Transcription-Coupled Nucleotide Excision Repair and Is Correlated with XPG Expression in Solid Tumor Cells

Florence Koeppel, Virginie Poindessous, Vladimir Lazar, +3

Clinical Cancer Research

Trabectedin and Its C Subunit Modified Analogue PM01183 Attenuate Nucleotide Excision Repair and Show Activity toward Platinum-Resistant Cells

Daniele G. Soares, Miriana S. Machado, Céline J. Rocca, +7

Molecular Cancer Therapeutics

Tumor BiologyGenome InstabilityShow ActivityNer ActivityMedicine +11

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor

Paul Mésange, Virginie Poindessous, Michèle Sabbah, +3

Oncotarget

EGFR- and VEGF(R)-Targeted Small Molecules Show Synergistic Activity in Colorectal Cancer Models Refractory to Combinations of Monoclonal Antibodies

Virginie Poindessous, Djamila Ouaret, Karima El Ouadrani, +14

Clinical Cancer Research

Impaired fatty acid metabolism perpetuates lipotoxicity along the transition to chronic kidney injury

Anna Maria Rinaldi, Hélène Lazareth, Virginie Poindessous, +9

JCI Insight

The cellular prion protein controls the mesenchymal-like molecular subtype and predicts disease outcome in colorectal cancer

Delphine Le Corre, Alexandre Ghazi, Ralyath Balogoun, +18

EBioMedicine

Cell stress response impairs de novo NAD+ biosynthesis in the kidney

Yohan Bignon, Anna Maria Rinaldi, Zahia Nadour, +12

JCI Insight

Nad+ BiosynthesisCellular PhysiologyOxidative StressRenal FunctionAcute Kidney Injury +19

Marked activity of irofulven toward human carcinoma cells: comparison with cisplatin and ecteinascidin.

Virginie Poindessous, Florence Koeppel, Éric Raymond, +3

PubMed

The Antitumor Triazoloacridone C-1305 Is a Topoisomerase II Poison with Unusual Properties

Krzysztof Lemke, Virginie Poindessous, Andrzej Składanowski, +1

Molecular Pharmacology