Alexandre E. Escargueil

The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane

Alexia Garrigues, Alexandre E. Escargueil, Stéphane Orlowski · Proceedings of the National Academy of Sciences · 2002 · 203 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743

Daniele G. Soares, Alexandre E. Escargueil, Virginie Poindessous et al. · Proceedings of the National Academy of Sciences · 2007 · 152 citations

Medicine, Oncology, Cancer Pharmacology +13

Emergence of Drug Tolerance in Cancer Cell Populations: An Evolutionary Outcome of Selection, Nongenetic Instability, and Stress-Induced Adaptation

Rebecca H. Chisholm, Tommaso Lorenzi, Alexander Lorz et al. · Cancer Research · 2015 · 148 citations · Full text

Life Sciences, Evolutionary Biology, Oncology +16

Modeling the Effects of Space Structure and Combination Therapies on Phenotypic Heterogeneity and Drug Resistance in Solid Tumors

Alexander Lorz, Tommaso Lorenzi, Jean Clairambault et al. · Bulletin of Mathematical Biology · 2014 · 123 citations · Full text

Medicine, Oncology, Pharmacology +17

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor

Paul Mésange, Virginie Poindessous, Michèle Sabbah et al. · Oncotarget · 2014 · 80 citations · Full text

Medicine, Cancer Biology, Pharmacology +17