Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation

Chao Yang, Ilaria Mogno, Eduardo J. Contijoch, +10

Cell Host & Microbe

Bacteroides OvatusDysbiosisMedicineGut MicrobiologyMicrobial Ecology +7

The IL-1 receptor accessory protein (AcP) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33

Gaby Palmer, Brian P. Lipsky, Molly D. Smithgall, +5

Cytokine

InflammationCytokineIl-33 SignalingMedicineSoluble St2 +8

SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm

Kevin J. Hamblett, Allison P. Jacob, Jesse L. Gurgel, +14

Cancer Research

Protein SecretionDrug TargetingNatural SciencesLysosomal TransporterImmunology +13

AMG 595, an Anti-EGFRvIII Antibody–Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma

Kevin J. Hamblett, Carl J. Kozlosky, Sophia Siu, +11

Molecular Cancer Therapeutics

Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19

Graham J. Britton, Alice Chen-Liaw, Francesca Cossarini, +24

Scientific Reports

Human gut microbiota stimulate defined innate immune responses that vary from phylum to strain

Matthew P. Spindler, Sophia Siu, Ilaria Mogno, +5

Cell Host & Microbe

DysbiosisMucosal ImmunologyHost-microbe InteractionsMicrobiotaGut Microbiology +10

Altering Antibody–Drug Conjugate Binding to the Neonatal Fc Receptor Impacts Efficacy and Tolerability

Kevin J. Hamblett, Tiep Le, Brooke M. Rock, +8

Molecular Pharmaceutics

SARS-CoV-2-specific IgA and limited inflammatory cytokines are present in the stool of select patients with acute COVID-19

Graham J. Britton, Alice Chen-Liaw, Francesca Cossarini, +22

Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism

Ruwanthi N. Gunawardane, Preston Fordstrom, Derek E. Piper, +16

Journal of Biological Chemistry

BiochemistryImmunologyLipoprotein MetabolismMedicineAtherosclerosis +2

Fusion partners can increase the expression of recombinant interleukins via transient transfection in 2936E cells

Jane Carter, Jue Zhang, T T Dang, +11

Protein Science

ImmunologyImmune RegulationTransient TransfectionImmunologic MechanismImmune System +17