Stephen Castellino

An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016)

Joseph W. Polli, Katie Olson, John P. Chism et al. · Drug Metabolism and Disposition · 2008 · 253 citations

Medicine, Oncology, Pharmacology +17

The Role of Efflux and Uptake Transporters in N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, Lapatinib) Disposition and Drug Interactions

Joseph W. Polli, Joan E. Humphreys, Kelly A. Harmon et al. · Drug Metabolism and Disposition · 2008 · 250 citations

Medicine, Oncology, Pharmacology +17

A Mimetic Tissue Model for the Quantification of Drug Distributions by MALDI Imaging Mass Spectrometry

M. Reid Groseclose, Stephen Castellino · Analytical Chemistry · 2013 · 205 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +15

Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer

Kunal S. Taskar, Vinay Rudraraju, Rajendar K. Mittapalli et al. · Pharmaceutical Research · 2011 · 202 citations · Full text

Medicine, Cancer Biology, Oncology +16

Synthesis and Characterization of Two Aromatic Silicon-Containing Dianions:The 2,3,4,5-Tetraphenylsilole Dianion and the 1,1'-Disila-2,2',3,3',4,4',5,5'-Octaphenylfulvalene Dianion

Jang‐Hwan Hong, Philip Boudjouk, Stephen Castellino · Organometallics · 1994 · 142 citations

Natural Sciences, Chemistry, Inorganic Chemistry +6