Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against <i>Plasmodium falciparum</i>, <i>Trypanosoma brucei</i>, and <i>Trypanosoma cruzi</i>

Doron C. Greenbaum, Zachary B. Mackey, Elizabeth Hansell, +7

Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryPlasmodium FalciparumBiochemistryAntiparasitic Agent +13

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

Eric M. Guantai, Kanyile K. Ncokazi, Timothy J. Egan, +4

Bioorganic & Medicinal Chemistry

Vitro Antimalarial EvaluationMedicinal ChemistryTriazole-linked ChalconeAntiparasitic AgentMedicine +6

Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents

Kelly Chibale, Mark Visser, Donelly A. van Schalkwyk, +3

Tetrahedron

Medicinal ChemistryBiochemistryAntiparasitic AgentXanthene DerivativesMedicine +8

Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives

Idan Chiyanzu, Cailean Clarkson, Peter J. Smith, +4

Bioorganic & Medicinal Chemistry

Bioorganic ChemistryBiochemistryMedicineNatural SciencesAnti-plasmodial Evaluation +5

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

Christel Brunschwig, Nina Lawrence, Dale Taylor, +45

Antimicrobial Agents and Chemotherapy

3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential

Yassir Younis, Frédèric Douelle, Tzu‐Shean Feng, +20

Journal of Medicinal Chemistry

Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

Kelly Chibale, Hayley Haupt, Howard Kendrick, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceBiochemistryAntiparasitic AgentMedicine +10

Enone– and Chalcone–Chloroquinoline Hybrid Analogues: In Silico Guided Design, Synthesis, Antiplasmodial Activity, in Vitro Metabolism, and Mechanistic Studies

Eric M. Guantai, Kanyile K. Ncokazi, Timothy J. Egan, +6

Journal of Medicinal Chemistry

Chalcone–chloroquinoline Hybrid AnaloguesLow PhBiochemistryAntiparasitic AgentMedicine +13

Pyrrolo[3,4-<i>c</i>]pyridine-1,3(2<i>H</i>)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration

Renier van der Westhuyzen, Susan Winks, Colin R. Wilson, +19

Journal of Medicinal Chemistry

Antimicrobial ChemotherapyPharmaceutical ChemistryDrug ResistanceM. TuberculosisMycobacterium Tuberculosis +17

Novel Orally Active Antimalarial Thiazoles

Diego González Cabrera, Frédèric Douelle, Tzu‐Shean Feng, +11

Journal of Medicinal Chemistry

Antiparasitic AgentMalariaCellular PharmacologyPharmacokineticsPre-clinical Pharmacology +16