Friederike Zunke

α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

Joseph R. Mazzulli, Friederike Zunke, Ole Isacson et al. · Proceedings of the National Academy of Sciences · 2016 · 378 citations · Full text

Molecular Biology, Protein Aggregates, Synaptic Signaling +24

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

Dante Neculai, Michael Schwake, Mani Ravichandran et al. · Nature · 2013 · 282 citations

Crystal Structure, Theoretical Inorganic Chemistry, Molecular Biology +5

Activation of  -Glucocerebrosidase Reduces Pathological  -Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons

Joseph R. Mazzulli, Friederike Zunke, Taiji Tsunemi et al. · Journal of Neuroscience · 2016 · 273 citations · Full text

Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide

Friederike Zunke, Alexandra C. Moise, Nandkishore R. Belur et al. · Neuron · 2017 · 221 citations · Full text

Biochemistry, Protein Folding, Natural Sciences +8

Detection of neuron-derived pathological α-synuclein in blood

Annika Kluge, Josina Bunk, Eva Schaeffer et al. · Brain · 2022 · 215 citations · Full text